Ethylmagnesium Bromide

Ethylmagnesium bromide

CAS No.: 925-90-6

Molecular Formula: C2H5BrMg

Molecular Weight: 133.27

Basic Information

Appearance: Gray to brownish solution

Density: 1.01 g/ml (25℃)

Boiling Point: 66℃, 80℃ (refers to the solvent, not the solute)

Flash Point: -5℃

Concentration: 1.0M, 2.0M (solutions in tetrahydrofuran, 2-methyltetrahydrofuran)

Properties

Violent reaction with water: Extremely sensitive to air and moisture, reacts violently with water to release highly flammable ethane gas.

Highly flammable: In humid air, violent exothermic reaction occurs, releasing highly flammable ethane gas.

Stability: Should be operated and stored under the protection of anhydrous and oxygen-free inert gases such as nitrogen or argon. Avoid contact with oxidants, acids, alcohols, etc. at room temperature.

Applications

1. Pharmaceutical industry: As a key intermediate for the synthesis of various drug molecules, especially for introducing ethyl groups or modifying drug skeletons by constructing carbon-carbon bonds to improve drug activity and pharmacokinetic properties. An important example is triethylsilane, a key intermediate used in the production of oseltamivir (trade name Tamiflu), an anti-influenza drug.

2. Organic synthesis: As a classic Grignard reagent, it is used to synthesize various fine chemicals such as alcohols, aldehydes, ketones and carboxylic acids through nucleophilic addition reactions with carbonyl compounds such as aldehydes, ketones and esters. It is an indispensable tool in the synthesis of complex organic molecules that require efficient carbon-carbon bond construction.

3. Special material synthesis: Used in the synthesis of photoresist materials for photolithography processes in the semiconductor and microelectronics manufacturing fields (2-alkyl-2-adamantanols are synthesized by adding additives such as zinc chloride or lithium chloride to optimize the reaction).

Packaging/Storage

1. 500ml glass bottles; 200L iron drums and steel cylinders.

2. During use, this product should be isolated from air and moisture to the greatest extent, and it is best to use it up once opened. Slight color difference or trace precipitation in the product will not affect its performance.

3. Store at room temperature.