7-Ethyl-10-hydroxy-camptothecin 99%

CAS#: 86639-52-3

Main Contents: 7-Ethyl-10-hydroxy-camptothecin

Plant Resource: Camptotheca acuminata
Main Specification: 99% HPLC

Appearance: Light Yellow Needle-like crystal
Plant Part Used: Fruit
Extract Solution: Ethanol

Molecular Weight: C₂₂H₂₀N₂O₅

Molecular Mass: 392.40

Solubility: Soluble in Ethanol

What is Camptotheca acuminata?

The Happy Tree, Cancer Tree, or Tree of Life (Camptotheca acuminata) is a genus of medium-sized deciduous trees growing to 20 m tall, native to southern China and Tibet. They are usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. Camptotheca is used to make Irinotecan, Topotecan, 9-Aminocamptothecin, and camptothecin-1 (CPT-1). It also contains trifolin and hyperoside.

What is 7-Ethyl-10-hydroxy-camptothecin?

7-Ethyl-10-hydroxy-camptothecin for CPT derivative product of nearly pure white needle-like crystals, dissolved in dimethyl - Oxide, micro-soluble in methanol, ethanol, in the water and almost insoluble in chloroform, ethanol and DMF in the heat of the solubility of larger,
Mp.224 ° C. mainly used for preparation of anticancer drug irinotecan hydrochloride. SN-38 and can also be VP-16, doxorubicin, Bleomycin in the treatment of non-small cell lung cancer, colorectal cancer, and so on.

Where will 10-Hydroxy camptothecin be used for?

SN-38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is metabolized via glucoronidation by UGT1A1.

The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of Irinotecan predicts Irinotecan toxicity, as it cannot be excreted from the body in its SN-38 form.

SN-38 is lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered Irinotecan.

Packing Detail:Packed in paper-drums and two plastic-bags inside. Net Weight: 25kgs/drum. I.D. 40CmX50CM
Storage Situation:Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.
Shelf Life:Two years under well Storage situation and stored away from direct sun light.

CAS NO:86639-52-3;130194-92-2;119577-28-5;130144-34-2;110714-48-2;113015-38-6

EC NO:

Molecular Formula:C₂₂H₂₀N₂O₅

Molecular Weight:392.4

Synonyms:;1h-pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4h,12h)-dione, 4-ethyl-4,10-dihydroxy-;7-ethyl-10-hydroxy camptothecin;7-ethyl-10-hydroxy-camptothecine;4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione;(4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-Ethyl-10-Hydroxy-Camptothecin;SN-38;7-Ethyl-10-hydroxycamptothecine;Intermediate of Irinotecan 1;

Molecular Structure: