Ethyl 4-bromobutyrate Preparation Process

The invention belongs to the technical field of ethyl 4-bromobutyrate preparation and proposes a one-step preparation method for ethyl 4-bromobutyrate, including: Step 1, under water bath and constant stirring conditions, add γ-butyrolactone to a container and control the water bath temperature to 10-30°C; Step 2, slowly introduce dry hydrogen bromide gas; Step 3, after the introduction of hydrogen bromide gas is complete, control the reaction temperature to 0-50°C and continue stirring for 1-3 hours; Step 4, add anhydrous ethanol and control the water bath to a constant temperature of 10-90°C until the reaction is complete; Step 5, after the reaction, add an appropriate amount of deionized water for washing, stir thoroughly, let stand for layering, take the lower organic phase, add saturated NaHCO3 solution, adjust pH to 7.0, let stand for layering, take the lower organic phase, wash with deionized water, stir thoroughly, let stand for layering, and separate the organic layer; Step 6, add a desiccant to dry and obtain ethyl 4-bromobutyrate. A one-step preparation process suitable for industrial-scale production of ethyl 4-bromobutyrate.

Introduction to Ethyl 4-bromobutyrate

Ethyl 4-bromobutyrate is a carboxylic acid ester derivative, appearing as a colorless transparent to yellow liquid. It is used as an intermediate in pesticides and pharmaceuticals and can be used in laboratory R&D and chemical production processes.